几乎所有的英文SCI文章在经过审稿以后是需要返修的，要求我们按审稿专家的意见对文章进行修改和标注。除了修改稿以外，我们还需要提供一个回复信，并对评审专家的提问进行逐一回复，称为“Point-to-point response letter”。
在此我给大家分享Point-to-point response letter的基本写法
：
第一
，切记
一定要感谢审稿人对文章提出的宝贵意见
。态度要诚恳，语气要和善。
第二
，通常审稿人会对自己提出的问题进行编号，这种情况比较常见，我们则需要
按照问题编号进行逐一回复
。如果审稿人没有自行编号，而是发了一段或者几段很长的话，问题也含糊不清，这种情况下就需要我们
对审稿意见进行整合和凝练
，
分成几个问题之后再进行逐一回复
。
第三
，
将审稿人的意见用斜体标记出来，这样一目了然，然后逐一回复
（正常的字体），回复时，以Author reply或者Response等字眼开头，这样审稿人可以很轻松地区分问题和回复意见。此外，对于文章中做出的标记，用不同颜色的字体标记出来，这样审稿人不需要再回到论文中去找，非常方便。
举例：
1.EGFR mutations are quite common in NSCLC. In Line 124-125 the authors state that EGFR20ins NSCLC are not sensitive to EGFR-TKIs, but do not provide any further explanation on the mechanism. As this Case-Study is focused on this specific mutation, it would add to the value of the manuscript, if the authors spend more time in explaining the molecular relevance of EGFR20ins mutations in NSCLC before listing several treatment options.
Author reply:
Thank the reviewer for this insightful suggestion. We added the explanation on the mechanism to the discussion section.
Changes in the text: The underlying mechanism is that EGFR ex20ins mutation alters the conformation at the kinase active site, limiting the binding of early-generation EGFR-TKIs.
Page and Line Number(s): Page 4 lines 132-135.
2.The Proposed Approach section is not clear; you need to justify why you choose this method among the others.
Response:
We appreciate the good advice. We have added the reason why we choose WES to the Discussion section (page 6 lines 132-136).
Changes in the text: In this study, we selected WES to detect the mutations in the patient, as it is a widely used next-generation sequencing (NGS) method that sequences all the protein-coding regions of the genome. The human exome represents < 2% of the genome; nevertheless, it contains up to 85% of known disease-associated variants, rendering WES a cost-effective alternative to whole-genome sequencing (WGS).
第四，
需要补充实验的，能做到就做，不能做的就向审稿人表示目前没有实验条件，后期如果条件成熟了，一定会进行审稿人说的相关研究，然后把这部分内容写到discussion部分，审稿人觉得受到了尊重，基本不会说什么。
第五，
如果审稿人和我们对某个观点有分歧，要谨慎回答，可以解释，但一定要圆滑，切记
不要与审稿人和编辑发生争执
。
第六，
如果有的意见实在离谱没法修改，那就尽可能地解释和说明，实在不行就诚恳的表态，说这次确实是我们哪里做的不好，但是也在文中解释了这个局限性，以后的实验里一定如何如何就行了，再感谢一下审稿人的提醒，最后基本都没问题的。
第七
，要注意回复的时间，
千万不能超过
deadline
，
但是也不能太快回复
，
要间隔一段时间，
以示重视
。
最后，祝大家多发高质量的文章！
下面我给出一个写作模板，也是我一直以来使用的模板，以供大家参考：
模板：
Dear Editors and Referees:
Thank you for your letter and for the Referees’ comments concerning our manuscript entitled“………(标题)” (………(稿件ID号)).Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our further researches. We have studied these comments carefully and have made correction which we hope meet with approval. Revised portion have been marked using the highlight in………(杂志要求的修改标记颜色)in the paper. The main corrections in the paper and the point-by-point responses to the Referees’ comments are as following:
Response toReview 1
审稿意见1
Response:
审稿意见２
Response:
．．．．．．
Response toReview 2
审稿意见1
Response:
审稿意见２
Response:
．．．．．．
Response to Review 3
审稿意见1
Response:
审稿意见２
Response:
．．．．．．
Special thanks to you for your good comments. We tried our best to improve the manuscript as your suggestion. And here we did not list all the changes but marked all the amends in revised paper.
We appreciate for your warm work earnestly, and hope that the correction will meet with approval. Thank you for the kind advice again. If you have any questions, please contact us without hesitate.
Yours sincerely,
通讯作者的姓名
