专栏名称: 亚盛医药

亚盛医药（6855.HK）是一家立足中国、面向全球的处于临床阶段的原创新药研发企业，专注于在肿瘤、乙肝及与衰老相关的疾病等治疗领域开发创新药物。公司拥有自主研发的蛋白-蛋白相互作用靶向药物设计平台，在细胞凋亡领域的研发颇为突出。

Ascentage to Present Three Preclinical Studies at AACR 2024

亚盛医药 · 公众号 · · 2024-03-06 07:48

正文

Ascentage Pharma (6855.HK) announced today that the latest results from three preclinical studies of the company’s novel drug candidates olverembatinib, MDM2-p53 inhibitor alrizomadlin, FAK/ALK/ROS1 tyrosine kinase inhibitor APG-2449, and EED inhibitor APG-5918, have been selected for presentations at the 2024 American Association of Cancer Research Annual Meeting (AACR 2024). These abstracts are now available on the AACR’s official website.

The AACR annual meeting is one of the world’s largest and longest-standing scientific gatherings in the field of cancer research. Covering some of the most cutting-edge advances in all the areas of oncology research and innovation, the annual event attracts tremendous interest from the global cancer research community. This year’s AACR annual meeting will be held from April 5-10 2024, in San Diego, California, USA.

These three preclinical abstracts from Ascentage Pharma include：

Olverembatinib, a novel multikinase inhibitor, demonstrates superior antitumor activity in succinate dehydrogenase (SDH)-deficient neoplasms

Abstract#

1971

Session Category

Experimental and Molecular Therapeutics

Session Title

Kinase and Phosphatase Inhibitors 2

Time

Pacific Time

Monday April 8, 2024, 9:00 AM - 12:30 PM

Results from this preclinical study show that in SDH-deficient cancer cells, olverembatinib has superior efficacy compared to other approved tyrosine kinase inhibitors. Mechanistically, olverembatinib can exert its antitumor effects in SDH-deficient neoplasms by modulating multiple signal pathways involved in cell hypoxia, angiogenesis, proliferation, and survival. These results provide a scientific rationale for the future development of olverembatinib in SHD-deficient cancers with an urgent unmet medical need.

Embryonic ectoderm development (EED) inhibitor APG-5918 (EEDi-5273) and MDM2 inhibitor alrizomadlin (APG-115) synergistically inhibit tumor growth in preclinical models of prostate cancer (PCa)

Abstract#

3223

Session Category

Experimental and Molecular Therapeutics

Session Title

Epigenetic Targets

Time

Pacific Time

Monday April 8, 2024, 1:30 PM - 5:00 PM,

Results from this preclinical study show that in preclinical models of PCa, targeting both EED and MDM2 can synergistically enhance antitumor activities by modulating pathways related to DNA methylation, cell cycle, and apoptosis. These findings provide a scientific rationale for the future clinical development of APG-5918 in combination with alrizomadlin for the treatment of PCa.

APG-2449, a novel focal adhesion kinase (FAK) inhibitor, inhibits metastasis and enhances the antitumor efficacy of PEGylated liposome doxorubicin (PLD) in epithelial ovarian cancer (EOC)

Abstract#

4569

Session Category

Experimental and Molecular Therapeutics

Session Title

Drug Combinations

Time

Pacific Time

Tuesday April 9, 2024, 9:00 AM - 12:30 PM