A postdoctoral fellow position is available in a new laboratory, Azusa Inoue’s Lab.The lab studies mechanisms and functions of epigenetic reprogramming inmammalian early embryos. The lab is located at RIKEN Center for IntegrativeMedical Sciences (IMS) at Yokohama, Japan. We are seeking a Ph.D (or candidate)with strong bioinformatics background.
We are looking for a person whomeets the qualification below;
• Ph.D.(or candidate) with excellent bioinformatics skills, such as integrated dataanalyses for RNA-seq, ChIP-seq, DNA methylome, and ATAC-seq data sets, etc
• Personwith self-motivation and written/oral communication skills
• Genomeor epigenome biology background are preferred, but not required
[Inoue’s research]
Ihave been interested in epigenetic regulations and functions in mammalianoocytes and preimplantation embryos in which the epigenetic landscape isdrastically reprogrammed at genome wide. In the past, I have studied themechanism of paternal DNA demethylation (1-5), the mechanism and function ofpaternal nucleosome assembly (6), the developmental dynamics of accessiblechromatin structures (7), and discovered a new genomic imprinting mechanismmediated by maternal histone methylation (8, 9). I integrate oocyte/embryomicromanipulation techniques (3-10), maternal protein depletion system (6, 10),and low-input cutting-edge chromatin analysis technologies (4, 7-9). In thefuture, I will study the mechanisms and functions of histone-dependent genomicimprinting and transgenerational epigenetic inheritance.
*References
1. Inoue and Zhang, 2011 Science334(6053):194.
2. Inoue et al., 2011 CellResearch 21(12):1670-6.
3. Inoue et al., 2012 CellResearch 22(12):1640-9.
4. Shen*, Inoue*(co-first) et al., 2014 Cell Stem Cell 15, 459-70.
5. Inoue et al., 2015 CellReports 10(4), 463-70.
6. Inoue and Zhang, 2014 NatureStruct Mol Biol 21, 609-16.
7. Lu*, Liu*, Inoue*(co-first) et al., 2016 Cell 165(6), 1375-88.
8. Inoue et al., 2017 Nature 547(7664), 419-24.
BioArt (Chinese): http://mp.weixin.qq.com/s/TI2Pgdl8YDKzyYpZN7AYGg
HHMI (English): http://www.hhmi.org/news/scientists-identify-new-way-cells-turn-genes
9. Inoue et al., 2017 GenesDev. 31(19) 1927-32.
10. Inoue et al., 2014 ProtocolExchage doi:10.1038/protex.2014.024
[Inoue’s carrier]
2011 Ph.D. at University of Tokyo, Japan
2011-12 Postdoc at Yi Zhang lab in University of North Carolina atChapel Hill, USA
2012-15 Postdoc at Yi Zhang lab in Harvard Medical School/Boston Children’sHospital
2015-18 Research Specialist at Yi Zhang lab/HHMI
2018- Young Chief Investigator at RIKEN IMS, Yokohama, Japan
[The purpose of this recruitment]
Recentinnovations have made it possible to profile epigenetic modifications at asingle locus level in rare biological samples, such as mammalian oocytes andpreimplantation embryos. More and more NGS data will be accumulated in thisfield in the next years. The following main stream will definitely be‘manipulation’ of the epigenome to understand its biological functions. Tomaterialize this, embryologists and bioinformaticians have to cooperate moreclosely. Since this field has far-reaching impacts on human society and medicalsciences including artificial reproductive technologies, regenerative medicine,and agriculture, it will become a more attractive content in the near future. Iam seeking my research partner with high motivation and strong bioinformaticskills. If a successful candidate desires, I am happy to teach wet experimentsincluding micromanipulation techniques and cutting-edge chromatin technologiesso he/she prepares for establishing their own labs.
[Terms of contract]
One-year fixed-term employment contract, renewable based on evaluation, up to three years since the initial date of hire. The period may be extended depending on the budget situation, etc.
Salary is determined annually on the basis of the employee's experience, abilities and research results.Commuting and housing allowances will be provided in accordance with RIKEN regulations and social insurance applies (health insurance, pension insurance, worker's accident compensation insurance, unemployment insurance, etc.). Mandatory membership in the RIKEN Mutual Benefit Society (RIKEN Kyosaikai).
Holidays: Saturdays and Sundays, Japanese national holidays, New Year holidays (Dec.29-Jan.3), and RIKEN Foundation Day (4th Monday in October).
[Location]
RIKEN Center for IntegrativeMedical Sciences (IMS)
1-7-22 Suehiro-cho, Tsurumi-ku,Yokohama, Kanagawa, 230-0045, Japan
http://www.ims.riken.jp/english/about/access.php
[Application deadline]
Until the position is filled
[Start of employment]
As early as Apr 1st, 2018(Negotiable)
[Application]
Please send a cover letter andyour CV with a photograph and a publication list to Inoue (azusa.inoue [at]childrens.harvard.edu) by e-mail.Please write all documents in English or Japanese.
[Selection process]
Skype interview after documentscreening.
We will offer a briefbioinformatic skill test for successful candidates of the Skype interview.
The result will be informed bye-mail.
[Contact information]
Azusa Inoue
[email protected] or [email protected]
