【八月福州·合成】聂尧：主要研究酶蛋白质工程改造策略、氧化还原酶不对称催化机制及其反应体系等~

江南大学 副院长/教授

聂尧，江南大学生物工程学院副院长，工业生物技术教育部重点实验室副主任，教授，博士生导师。入选国家特殊支持计划人才、江苏省“六大人才高峰”高层次人才、江苏省“青蓝工程”中青年学术带头人、江苏省第四期“333工程”中青年科学技术带头人。兼任中国化工学会生物化工专业委员会常务委员、中国食品科学技术学会酶制剂分会副主任委员。

主要开展酶蛋白质工程改造策略、氧化还原酶不对称催化机制及其反应体系等研究

主持国家和省部级项目12项；在ACS Catalysis等发表论文160多篇；申请发明专利27项，授权发明专利20项；获得教育部技术发明奖一等奖、江苏省科学技术奖二等奖、中石化联合会技术发明奖一等奖、中石化联合会青年科技突出贡献奖等科研奖励。

*仅举例其中5篇

1、Lunjie Wu, Jianhong An, Xiaoran Jing, Chun-Chi Chen, Longhai Dai, Yan Xu, Weidong Liu,* Rey-Ting Guo,* and Yao Nie*. Molecular insights into the regioselectivity of the Fe(II)/2-ketoglutarate-dependent dioxygenase-catalyzed C−H hydroxylation of amino acids. ACS Catalysis, 2022 , 12: 11586-11596.

2、Lunjie Wu, Lei Qin, Yao Nie, Yan Xu, Yi-Lei Zhao. Computer-aided understanding and engineering of enzymatic selectivity. Biotechnology Advances, 2022 , 54: 107793

3、Jie Gu, Byu Ri Sim, Jiarui Li, Yangqing Yu, Lei Qin, Lunjie Wu, Yu Shen, Yao Nie, Yi-Lei Zhao, Yan Xu. Evolutionary coupling-inspired engineering of alcohol dehydrogenase reveals the influence of distant sites on its catalytic efficiency for stereospecific synthesis of chiral alcohols. Computational and Structural Biotechnology Journal, 2021 , 19: 5864-5873.

4、Jiahua Bi, Xiaoran Jing, Lunjie Wu, Xia Zhou, Jie Gu, Yao Nie, Yan Xu. Computational design of noncanonical amino acid-based thioether staples at N/C-terminal domains of multi-modular pullulanase for thermostabilization in enzyme catalysis. Computational and Structural Biotechnology Journal, 2021 , 19: 577-585.

5、Lei Qin, Lunjie Wu, Yao Nie, Yan Xu. Biosynthesis of chiral cyclic and heterocyclic alcohols via C=O/C-H/C-O asymmetric reactions. Catalysis Science & Technology, 2021 , 11:2637-2651.