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赵林教授|回顾 2024 ESMO 结直肠癌进展,探索结直肠癌诊疗新机遇

丁香园肿瘤时间  · 公众号  · 医学  · 2024-12-15 20:20

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本文仅供中国大陆地区执业的医学药学专业人士参考,如您非前述专业人士,请离开本页面


精彩内容抢先看:

结直肠癌免疫治疗持续探索不断取得新突破

抗血管生成药物三线治疗 mCRC 再添新证

免疫、靶向及新药探索为结直肠癌带来新希望

赵林 教授

北京协和医院




博士,主任医师

北京协和医院肿瘤内科  副主任

北京肿瘤防治研究会消化肿瘤专家委员会 主任委员   

北京抗癌协会食管癌专业委员会 副主任委员    

北京肿瘤病理精准诊断研究会 副会长  

国家肿瘤专业医疗质量指控中心  副主任委员

中国抗癌协会多原发和不明原发肿瘤专委会   常委委员

北京医学会肿瘤学分会 委员

CSCO 结直肠癌、食管癌专家委员会 委员

肖像获得专家知情同意

审批码:PP-FR-CN-1374


参考文献:

[1]  Chalabi M, et al. Neoadjuvant immunotherapy in locally advanced MMR-deficient colon cancer: 3-year disease-free survival from NICHE-2. 2024 ESMO LBA24.

[2]  GOOYER P D, VERSCHOOR Y, DUNGEN L V, et al. Neoadjuvant nivolumab plus Relatlimab in MMR-deficient Colon Cancer: Results of the NICHE-3 Study. 2024 ESMO. 503O.

[3]  中国临床肿瘤学会(CSCO).《结直肠癌诊疗指南 2024》.

[4]  Tougeron D,et al. Pembrolizumab in combination with CAPOX and bevacizumab in patients with microsatellite stable metastatic colorectal cancer and a high immune infiltrate: preliminary results of FFCD 1703 POCHI trial.2024 ESMO 502O.

[5]  Ng K, et al.SOLARIS (Alliance A021703): A multicenter double-blind phase III randomized clinical trial (RCT) of vitamin D (VitD) combined with standard chemotherapy plus bevacizumab (bev) in patients (pts) with previously untreated metastatic colorectal cancer (mCRC).2024 ESMO LBA26.

[6]  Li J, Qin S, Xu RH, et al. Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial. JAMA. 2018 Jun 26;319(24):2486-2496.

[7]  Dasari A,et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. Lancet. 2023;402(10395):41-53.

[8]  https://www.nmpa.gov.cn/zhuanti/cxylqx/cxypxx/20180905101101372.html

[9]  https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fruquintinib-refractory-metastatic-colorectal-cancer

[10]  HUTCHMED Announces European Commission Approval for FRUZAQLA® (fruquintinib) Received by Takeda. Retrieved June 21, 2024 from https://www.globenewswire.com/news-release/2024/06/21/2902512/0/en/HUTCHMED-Announces-European-Commission-Approval-for-FRUZAQLA-fruquintinib-Received-by-Takeda.html

[11]  Garcia-Carbonero G, et al. Efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer with and without liver metastasis: A subgroup analysis of the phase III FRESCO-2 trial.2024 ESMO 520Р.

[12]  Elez Fernandez M.E, et al. Efficacy and safety of fruquintinib in refractory metastatic colorectal cancer: A FRESCO-2 subgroup analysis by age.2024 ESMO 526Р.

[13]  Siena S, et al. Sotorasib (soto), panitumumab (pani) and FOLFIRI in the first-line (1L) setting for KRAS G12C-mutated metastatic colorectal cancer (mCRC): Safety and efficacy analysis from the phase Ib CodeBreaK 101 study.2024 ESMO 505O.

[14]  Tabernero J, et al. Encorafenib + cetuximab (EC) + FOLFIRI for BRAF V600Emutant metastatic colorectal cancer (mCRC): Updated results from the BREAKWATER safety lead-in (SLI).2024 ESMO 515MO.

[15]  Pietrantonio F, et al. Amivantamab plus FOLFOX or FOLFIRI in metastatic colorectal cancer: Results from OrigAMI-1, an open-label, phase Ib/ll study.2024 ESMO 513MO.

[16]  Hendifar A, et al. Phase Ib/ll study of ompenaclid (RGX-202-01), a first-in-class oral inhibitor of the creatine transporter SLC6A8, in combination with FOLFIRI and bevacizumab (BEV) in RAS mutated (RASmt) second-line (2L) advanced/metastatic colorectal cancer (mCRC): Updated results.2024 ESMO 575Р.


*此文仅用于向医疗卫生专业人士提供科学信息,不代表平台立场


✩ 本文仅供医疗卫生等专业人士参考


内容策划:季慧敏

项目审核:李淳

题图来源:丁香园设计