药明康德/报道
The laboratory of
Dr. Patrick Ellinor
at the Massachusetts General Hospital and the Broad Institute is looking for postdoctoral fellows to join our research efforts.
We are looking for highly motivated and talented individuals who will collaborate with computational biologists, laboratory scientists, and clinicians in a collegial work environment characterized by informality and intellectual rigor.
The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. He or she must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, and demonstrate strong interpersonal skills to enable collaboration with project teams, and peers, for identifying and achieving research goals.
Specifically, the candidates will conduct experimental research studies directed at characterizing the function of genes identified by large scale genetic studies of atrial fibrillation
Example projects include: determining the cellular localization of a candidate gene by immunohistochemistry; assessing the gene function by CRISPR mediated knockout in iPSC derived cardiomyocytes; identifying interacting partners with the target protein; assessing the suitability of the gene for assay development; and developing assays for small molecule hit identification, validation, and mechanistic characterization.
Massachusetts General Hospital and the Broad Institute provide vibrant research environments with close links to top academic institutions across the Boston area and provide the potential for your contributions to be used and recognized worldwide.
REQUIREMENTS:
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Ph.D. in Biology (Developmental, Molecular, Cellular Biology), Biochemistry, or related life science field
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0-2 years of research in an industrial or academic setting with a proven record of successful interaction with team members
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Experience with mouse models for cardiovascular disease (genetics and surgical procedures) is a plus
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Hands-on experience in cellular assay development and proficiency with standard assay formats (e.g. flow cytometry, imaging, luminescence-/fluorescence-based cellular readouts, immunohistochemistry) in primary and cultured cells
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Experience with
CRISPR targeting ES/iPS cells and cardiomyocyte differentiation protocols
preferred
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Experience in recombinant protein purification, biochemical assay development and cellular pharmacology is a plus
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Ability to develop research plans for executing strategy, operate and maintain equipment, and perform laboratory work, with complete independence
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Track record of working on complex problems, and ability to integrate data from multiple disciplines
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Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
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Outstanding verbal and written communication abilities
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Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
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A passion for science and sense of urgency to find new medicines to benefit patients
