长期从事
微生物代谢的分子生物学研究
,主攻放线菌遗传学及抗生素生物合成的化学生物学,打开DNA硫修饰新领域,在国内外学术刊物上发表300 余篇研究论文。
主要从事
放线菌遗传学及抗生素生物合成的生物化学和分子生物学研究
。在链霉菌质粒和噬菌体的分子生物学,DNA复制调控、限制和修饰系统,微生物代谢途径、代谢工程及合成生物学创新等方面取得了系统性的科技成果。特别是首次在众多细菌DNA大分子上发现了硫修饰,这是在DNA骨架上发现的第一种生理性修饰，打开了DN硫修饰这个全新的科学领域。
谈家桢生命科学成就奖(2017)得主
*仅举例其中5篇
1.
Hui Tao#, Lukas Lauterbach#, Guangkai Bian#, Rong Chen, Anwei Hou, Takahiro Mori, Shu Cheng, Ben Hu, Li Lu, Xin Mu, Min Li, Naruhiko Adachi, Masato Kawasaki, Toshio Moriya, Toshiya Senda, Xinghuan Wang,Zixin Deng, Ikuro Abe*, Jeroen S. Dickschat* & Tiangang Liu*. Discovery of non-squalene triterpenes. Nature 2022, 606, pages414–419
2. Xiaolin Xiong#, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang,Zixin Deng, Jiawei Wang, Peter C Dedon, Shi Chen*, Lianrong Wang*. SspABCD–SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities. Nat Microbiol2020, 5(7):917-928
3. Hui Zhou#, Xiaodong Zeng, Anguo Li, Wenyi Zhou, Lin Tang, Wenbo Hu, Quli Fan, Xianli Meng, Hai Deng, Lian Duan, Yanqin Li,Zixin Deng, Xuechuan Hong, Yuling Xiao*.Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy. Nat Commun2020,11(1):6183
4. Ran Liu#, Yuchen Zhang, Guoqing Zhai, Shuai Fu, Yao Xia, Ben Hu, Xuan Cai, Yan Zhang, Yan Li,Zixin Deng, Tiangang Liu*.A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo. Adv Sci2020,7(17):2001616
5. Li Chen#, Nathchar Naowarojna, Heng Song, Shu Wang, Jiangyun Wang,Zixin Deng, C hangming Zhao, Pinghua Liu*. Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation. J Am Chem Soc 2018,140(13):4604-4612
