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小鼠
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人类
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B淋巴细胞祖细胞
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Lin- CD117- Ly6- Ly6D+ IL-7 Ra+ Flt-3+
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CD10+ CD34+ Pax5+
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B1祖细胞
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Lin- CD45R low CD19+ CD93+
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--
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B2祖细胞
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Lin- CD45R+ CD19- CD93-
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--
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Pre-Pro B cell
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Lin- CD45R+ CD19- CD24 low CD43+
CD93+ CD117- CXCR4+
FLt-3+ IL-7Ra+ IgM-
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CD117 low CD10+ CD34+ CD38+ Pax5+
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祖B细胞
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Lin- CD45R+ CD19+ CD24 + CD43+ CD117 low IL-7Ra+ IgM-
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CD117 low CD10+ CD19+ CD20+ CD24+ CD34+ CD38+ CD93+ IL3R+
IL-7 Ra+ Pax5+
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前B细胞
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Lin- CD45R+ CD19+ CD24 + CD43- IL-7Ra+ IgM-
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CD117- CD10+ CD19+ CD20+ CD24+ CD34- CD38+
CD93+ IL-3 R+
IL-4 Ra+ IL-7 Ra+ Pax5+
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未成熟B细胞
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CD45R+ CD19+ CD23- CD24+ CD43- CD93+ IgD- IgM+
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CD117- CD10+ CD19+ CD20+ CD21+ CD24+ CD27-
CD38+ CD40+
CD93+ IL-4 Ra+ IL-7 Ra
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B1a细胞
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CD1d mid CD5+ CD19 high CD23- CD43+
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--
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B1b细胞
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CD1d mid CD5- CD19 high CD23- CD43+
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--
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过渡性B细胞
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CD45R+ CD19+ CD24+ CD43- CD93+ IgM+ IgD low/+ (T1/T2)
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CD10 low CD5+ CD19+ CD20+ CD21+ CD23+ CD24+
CD27- CD38+
CD93+ TACI+
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边缘区B细胞
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CD45R+ CD1d+ CD19 mid CD21 high
CD23- CD43- CD93-
IgM high IgD low
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CD1c+ CD19+ CD20+ CD21+ CD27+
FCRL3+ TACI+
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滤泡B细胞
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CD45R+ CD1d mid CD19 mid CD21
low CD23+ CD43- CXCR5
+ IgM low IgD high
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CD10- CD19+ CD20+ CD21+ CD22+
CD23+ CD24 low CD27- CD38low CXCR5+ TAC+ MHC II+
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活化生发中心B细胞
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CD45R+ CD19+ CD40+ MHC II+
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CD19+ CD20+ CD27+ CD38+ CD40+
CD83+ TACI+ MHC II+
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记忆B细胞
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CD45R low CD19+ CD21+ CD27 mid/+ CD40+ MHC II+
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CD19+ CD20+ CD21+ CD27+ CD93-
TACI+
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浆母细胞
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CD45R low CD19+ CD27 high CD38+ CD138+
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BCMA+ CD19 low CD27 high CD38+ CD93+
CD138-/low
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浆细胞
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CD45R low BLIMP1+ CD19- CD27
high CD38 low CXCR4 high
CD138+ MHC II -/low
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BCMA+ BLIMP1+ CD19 low CD20-/low
CD27 high CD38 high CD138 + CXCR4+ MHC II low
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调节性B细胞
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CD1d+ CD5+ CD19+ CD23-/low CD24+ CD93-/low TIM-1+ IL-10+
IL-35+ TGF-b+
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CD1d+ CD5+ CD19+ CD21+ CD24+
IL-10+ IL-35+ TGF-b+
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