得克萨斯农工大学（Texas A&M University)
李平卫实验室招收两名博士后
Post-doc positions in the Department of Biochemistry and Biophysics at Texas A&M University
Posted 1/6/2025
Viral nucleic acids induce potent immune responses. The detection of viral DNA is a central strategy the host senses infection and initiates protective immune responses. The cGAS-STING pathway plays a central role in the immune response towards microbial infection. As a leader in the structural characterization of the cGAS-STING pathway, we have contributed significantly to this field. For example, we have determined the crystal structures of cGAS in complex with dsDNA (Xin Li et al. Immunity). We have also determined the structures of STING in complex with cGAMP (Chang Shu et al. NSMB). Moreover, we have solved the structures of TBK1 bound to STING (Baoyu Zhao et al. Nature). In our study last year, we have determined the structure of cGAS bound to the nucleosome core particle (NCP), revealing the molecular basis of cGAS inactivation by nuclear tethering (Baoyu Zhao et al. Nature). Their recent work revealed the mechanism of cGAMP export mediated by ABCC1 (Shinde et al. Immunity)
Two post-doc research associate positions are open in my lab to investigate the molecular basis of the cGAS-STING signaling pathway. Applicants in biochemistry, cell and molecular immunology, and structural biology are encouraged to apply. Texas A&M University is equipped state of the art facilities for cryo-EM and X-ray crystallography. A new Titan Krios microscope has been installed in my department this fall. Additional facilities for EM are available at the Center of Microscopy.
