专栏名称: 脑科学与脑技术

“严谨治学，协同创新”－发布港深地区脑科学学术交流信息、国际前沿脑技术进展与趋势。中国科学院深圳先进技术研究院－MIT麦戈文联合脑认知与脑疾病研究所（BCBDI)

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脑科学与脑技术 · 公众号 · · 2017-11-03 17:17

正文

BCBDI

中国科学院深圳先进技术研究院－MIT麦戈文联合脑认知与脑疾病研究所

The Brain Cognition & Brain Disease Institute for Collaboration Research of SIAT at CAS and the McGovern Institute at MIT

Academic Seminar

Glial Glycogen and Nervous System Energy Metabolism:

More Answers, More Questions

时间：

2017年11月4日上午10:00

地点：

先进院F栋13楼会议室

主持人：

王立平研究员

演讲嘉宾：

Bruce Ransome

Professor and Chair, Department of Neurology

Adjunct Professor, Department of Physiology and Biophysics

报告简介：

Glycogen is a brilliantly designed glucose storage molecule. While we understand quite precisely how glycogen functions in liver and muscle, this remains an emerging story for glycogen in the nervous system. In fact, the very existence of glycogen in normal peripheral nerve was only recently established. We have studied the physiology and functions of glycogen in CNS white matter and peripheral nerve, using acutely isolated mouse optic nerve (MON), a typical CNS white matter tract, and mouse sciatic nerve (MSN). These advantageous preparations allowed rigorously experimental assessment with quantitative electrophysiological techniques, including an ‘enzyme’ electrode for detecting lactate, biochemical glycogen assay and direct EM visualization of cytoplasmic glycogen particles.

A strategic partnership between neurons and glia:

health and disease

时间：

2017年11月4日上午11:00

地点：

先进院F栋13楼会议室

主持人：

王立平研究员

演讲嘉宾：

Youngjin Lee

Postdoctoral Fellow (Johns Hopkins University)

PhD (University of Alabama at Birmingham)

M.S. Pharm. & B. Pharm. (Sungkyunkwan University)

报告简介：

Dr Lee’s Lab focuses on developing new tools, particularly mouse models and viral delivery systems to comprehensively understand glia-neuron energy metabolic coupling in neurological diseases. Critical CNS energy substrates are glucose and monocarboxylates such as lactate and ketone bodies. Particularly, glia-neuron metabolic coupling via monocarboxylate transporters (MCTs) may be an essential element for proper CNS development, including myelin formation, axon and synapse maturation, and neuronal circuitry development as well as for the maintenance of axonal and neuronal integrity during neuropathogenesis. Therefore, the study of MCTs during neurodevelopment and neuropathogenesis will provide novel therapeutic targets for those diseases, and also facilitate the development and application of inhibitors or activators specific to MCTs to prevent disease progression.

All are welcome

联合脑认知与脑疾病研究所

麦戈文

脑科学研究所

中国科学院深圳先进技术研究院

脑科学与脑技术

微信号：BCBDInstitute

网址：www.siat.ac.cn

招生及导师信息：www.siat.ac.cn

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