【今天21:00】有机化学研讨会：有机合成中的自由基化学 II

# Chair

Louis Fensterbank obtained his PhD in 1993 from SUNY Stony Brook under the guidance of Scott Sieburth. After a lecturer position at the Université Pierre & Marie Curie (UPMC), he was appointed in 1995 as a CNRS Chargé de Recherche in Max Malacria’s lab. In 2004, he became Professor at UPMC, now Sorbonne Université. His research interests deal with the discovery of new molecular transformations relying on radical or organometallic processes and their applications to the synthesis of substrates with relevant properties. Co-author of more than 250 publications, he has received several awards, notably the Silver Medal of CNRS in 2017. He is Fellow of the Royal Society of Chemistry and member of the Academia Europaea. In 2023, he was hired by Collège de France and he now holds the Chair Activations in Molecular Chemistry.

# 1

Ketones are highly versatile building blocks present in countless natural products. This talk will explore the diverse reactivity of ketones under photocatalytic and electrochemical conditions, showcasing their potential for enabling a wide range of functionalizations to construct complex molecular structures.

# 2

Design and development of novel photocatalytic systems. From energy-transfer to electron-transfer processes

In this presentation, I will focus on two different topics from my research group, moving from the design of new photosensitizers to the development of powerful redox catalysts

1. Based on experimental evidences and mechanistic information, we have identify and structurally optimized a new family of photosensitiser. This class of molecules is characterized by a short S1-T1 gap. We observed and increased selectivity in the strain-release functionalization of azabyclic (abb) scaffolds. This new reaction manifold grants access to highly functionalized azetidine scaffolds.

2. We have designed and developed two new classes of photoredox catalysts (PCs) capable of activating diverse types of redox inert substrates. To do so, we have used i) a catalytic proton-coupled electron-transfer (PCET) manifold; and ii) an unconventional regenerative photocatalytic mechanism.

# 3

Harnessing Radical and Carbene Polarity

I will share some recent stories about how we applied new knowledge about the polarity of radicals and carbenes to develop important new synthetic methods.