【八月福州·合成】夏建业教授畅谈：合成生物学时代发酵过程数字化与智能化！

中科院天津工业生物技术研究所  研究员

夏建业，研究员，博士生导师，中科院百人计划入选者，中国微生物学会生化过程模型化与控制专委会副主任委员。

主持和参与了863计划、973计划、支撑计划、重点研发计划、国家自然科学基金、中荷国际等近10项研究课题，提出的基于反应器流场和细胞生理相结合的发酵过程优化放大方法在国内多家生物制造企业获得成功应用，曾获国家科技进步二等奖1项、上海市科技进步一等奖1项、中国轻工业联合会科技进步二等奖1项，在Cell, Nature Communications, Biotech. & Bioeng, Trends in Biotechnology等期刊发表研究论文30余篇，授权专利3项。

*仅举例其中5篇

1. Peng Liu, Ye Hua, Wei Zhang, Tingting Xie, Yingping Zhuang*, Jianye Xia *, Henk Noorman, 2021, A new strategy for dynamic metabolic flux estimation by integrating transient metabolome data into genome-scale metabolic models, Bioprocess and Biosystems Engineering , 44, 2553–2565.

2. Peng Liu, Shuai Wang, Chao Li, Yingping Zhuang, Jianye Xia*, Henk Noorman, 2021，Dynamic response of Aspergillus niger to periodical glucose pulse stimulus, Biotechnology and Bioengineering, 118(6):2265-2282.

3. Jingru Zhou, Yingping Zhuang, Jianye Xia*, 2021, Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions, Microbial Cell Factories, 20: 125.

4. Chao Li, Xiaonuo Teng, Huadong Peng, Xiaoping Yi, Yingping Zhuang, Siliang Zhang, Jianye Xia*, 2020, Novel scale-up strategy based on three-dimensional shear space for animal cell culture, Chemical Engineering Science, 212, 115329.

5.  Shuai Wang, Peng Liu, Wei Shu, Chao Li, Huan Li, Shanshan Liu, Jianye Xia*, Henk Noorman, 2019, Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations, Bioresources and Bioprocessing, 6(16).